Symptoms

Many women who have fibroids don't have any symptoms. In those that do, symptoms can be influenced by the location, size, and a number of fibroids.

In women who have symptoms, the most common signs and symptoms of uterine fibroids include:

● Heavy menstrual bleeding
● Menstrual periods lasting more than a week
● Pelvic pressure or pain
● Frequent urination
● Difficulty emptying the bladder
● Constipation
● Backache or leg pains

Rarely, a fibroid can cause acute pain when it outgrows its blood supply and begins to die.

Fibroids are generally classified by their location. Intramural fibroids grow within the muscular uterine wall. Submucosal fibroids bulge into the uterine cavity. Subserosal fibroids project to the outside of the uterus.

When to see a doctor

See your doctor if you have:

● Pelvic pain that doesn't go away
● Overly heavy, prolonged, or painful periods
● Spotting or bleeding between periods
● Difficulty emptying your bladder
● Unexplained low red blood cell count (anemia)

Seek prompt medical care if you have severe vaginal bleeding or sharp pelvic pain that comes on suddenly.

Causes

Doctors don't know the cause of uterine fibroids, but research and clinical experience point to these factors:

● Genetic changes. Many fibroids contain changes in genes that differ from those in typical uterine muscle cells.
● Hormones. Estrogen and progesterone, two hormones that stimulate the development of the uterine lining during each menstrual cycle in preparation for pregnancy, appear to promote the growth of fibroids.

Fibroids contain more estrogen and progesterone receptors than typical uterine muscle cells do. Fibroids tend to shrink after menopause due to a decrease in hormone production.

● Other growth factors. Substances that help the body maintain tissues, such as insulin-like growth factors, may affect fibroid growth.
● Extracellular matrix (ECM). ECM is the material that makes cells stick together, like mortar between bricks. ECM is increased in fibroids and makes them fibrous. ECM also stores growth factors and causes biological changes in the cells themselves.

Doctors believe that uterine fibroids develop from a stem cell in the smooth muscular tissue of the uterus (myometrium). A single cell divides repeatedly, eventually creating a firm, rubbery mass distinct from nearby tissue.

The growth patterns of uterine fibroids vary — they may grow slowly or rapidly, or they may remain the same size. Some fibroids go through growth spurts, and some may shrink on their own.

Many fibroids that have been present during pregnancy shrink or disappear after pregnancy, as the uterus goes back to its usual size.

Risk factors

There are few known risk factors for uterine fibroids, other than being a woman of reproductive age. Factors that can have an impact on fibroid development include:

● Race. Although all women of reproductive age could develop fibroids, black women are more likely to have fibroids than are women of other racial groups. In addition, black women have fibroids at younger ages, and they're also likely to have more or larger fibroids, along with more severe symptoms.
● Heredity. If your mother or sister had fibroids, you're at increased risk of developing them.
● Other factors. Starting your period at an early age; obesity; a vitamin D deficiency; having a diet higher in red meat and lower in green vegetables, fruit and dairy; and drinking alcohol, including beer, appear to increase your risk of developing fibroids.

Complications

Although uterine fibroids usually aren't dangerous, they can cause discomfort and may lead to complications such as a drop in red blood cells (anemia), which causes fatigue, from heavy blood loss. Rarely, a transfusion is needed due to blood loss.

Pregnancy and fibroids

Fibroids usually don't interfere with getting pregnant. However, it's possible that fibroids — especially submucosal fibroids — could cause infertility or pregnancy loss.

Fibroids may also raise the risk of certain pregnancy complications, such as placental abruption, fetal growth restriction, and preterm delivery.

Prevention

Although researchers continue to study the causes of fibroid tumors, little scientific evidence is available on how to prevent them. Preventing uterine fibroids may not be possible, but only a small percentage of these tumors require treatment.

But, by making healthy lifestyle choices, such as maintaining a healthy weight and eating fruits and vegetables, you may be able to decrease your fibroid risk.

Also, some research suggests that using hormonal contraceptives may be associated with a lower risk of fibroids.

Diagnosis

Uterine fibroids are frequently found incidentally during a routine pelvic exam. Your doctor may feel irregularities in the shape of your uterus, suggesting the presence of fibroids.

If you have symptoms of uterine fibroids, your doctor may order these tests:

●Ultrasound. If confirmation is needed, your doctor may order an ultrasound. It uses sound waves to get a picture of your uterus to confirm the diagnosis and to map and measure fibroids.

A doctor or technician moves the ultrasound device (transducer) over your abdomen (transabdominal) or places it inside your vagina (transvaginal) to get images of your uterus.

●Lab tests. If you have abnormal menstrual bleeding, your doctor may order other tests to investigate potential causes. These might include a complete blood count (CBC) to determine if you have anemia because of chronic blood loss and other blood tests to rule out bleeding disorders or thyroid problems.

Other imaging tests

If traditional ultrasound doesn't provide enough information, your doctor may order other imaging studies, such as:

● Magnetic resonance imaging (MRI). This imaging test can show in more detail the size and location of fibroids, identify different types of tumors, and help determine appropriate treatment options. An MRI is most often used in women with a larger uterus or in women approaching menopause (perimenopause).
● Hysterosonography. Hysterosonography, also called a saline infusion sonogram, uses sterile salt water (saline) to expand the uterine cavity, making it easier to get images of submucosal fibroids and the lining of the uterus in women attempting pregnancy or who have heavy menstrual bleeding.
● Hysterosalpingography. Hysterosalpingography uses a dye to highlight the uterine cavity and fallopian tubes on X-ray images. Your doctor may recommend it if infertility is a concern. This test can help your doctor determine if your fallopian tubes are open or are blocked and can show some submucosal fibroids.
● Hysteroscopy. For this exam, your doctor inserts a small, lighted telescope called a hysteroscope through your cervix into your uterus. Your doctor then injects saline into your uterus, expanding the uterine cavity and allowing your doctor to examine the walls of your uterus and the openings of your fallopian tubes.

Treatment

There's no single best approach to uterine fibroid treatment — many treatment options exist. If you have symptoms, talk with your doctor about options for symptom relief.

Watchful waiting

Many women with uterine fibroids experience no signs or symptoms, or only mildly annoying signs and symptoms that they can live with. If that's the case for you, watchful waiting could be the best option.

Fibroids aren't cancerous. They rarely interfere with pregnancy. They usually grow slowly — or not at all — and tend to shrink after menopause, when levels of reproductive hormones drop.

Medications

Medications for uterine fibroids target hormones that regulate your menstrual cycle, treating symptoms such as heavy menstrual bleeding and pelvic pressure. They don't eliminate fibroids but may shrink them. Medications include:

●Gonadotropin-releasing hormone (GnRH) agonists. Medications called GnRH agonists to treat fibroids by blocking the production of estrogen and progesterone, putting you into a temporary menopause-like state. As a result, menstruation stops, fibroids shrink and anemia often improves.

GnRH agonists include leuprolide (Lupron Depot, Eligard, others), goserelin (Zoladex), and triptorelin (Trelstar, Triptodur Kit).

Many women have significant hot flashes while using GnRH agonists. GnRH agonists typically are used for no more than three to six months because symptoms return when the medication is stopped and long-term use can cause loss of bone.

Your doctor may prescribe a GnRH agonist to shrink the size of your fibroids before planned surgery or to help transition you to menopause.

● Progestin-releasing intrauterine device (IUD). A progestin-releasing IUD can relieve heavy bleeding caused by fibroids. A progestin-releasing IUD provides symptom relief only and doesn't shrink fibroids or make them disappear. It also prevents pregnancy.
● Tranexamic acid (Lysteda, Cyklokapron). This non-hormonal medication is taken to ease heavy menstrual periods. It's taken only on heavy bleeding days.
● Other medications. Your doctor might recommend other medications. For example, oral contraceptives can help control menstrual bleeding, but they don't reduce fibroid size.

Nonsteroidal anti-inflammatory drugs (NSAIDs), which are not hormonal medications, may be effective in relieving pain related to fibroids, but they don't reduce bleeding caused by fibroids. Your doctor may also suggest that you take vitamins and iron if you have heavy menstrual bleeding and anemia.

Noninvasive procedure

MRI-guided focused ultrasound surgery (FUS) is:

● A non-invasive treatment option for uterine fibroids that preserves your uterus, requires no incision, and is done on an outpatient basis.
● Performed while you're inside an MRI scanner equipped with a high-energy ultrasound transducer for treatment. The images give your doctor the precise location of the uterine fibroids. When the location of the fibroid is targeted, the ultrasound transducer focuses sound waves (sonications) into the fibroid to heat and destroy small areas of fibroid tissue.
● Newer technology, so researchers are learning more about the long-term safety and effectiveness. But so far data collected show that FUS for uterine fibroids is safe and effective.

Preparing for your appointment

Your first appointment will likely be with either your primary care provider or a gynecologist. Because appointments can be brief, it's a good idea to prepare for your appointment.

What you can do

● Make a list of any symptoms you're experiencing. Include all of your symptoms, even if you don't think they're related.
● List any medications, herbs, and vitamin supplements you take. Include doses and how often you take them.
● Have a family member or close friend accompany you, if possible. You may be given a lot of information during your visit, and it can be difficult to remember everything.
● Take a notebook or electronic device with you. Use it to note important information during your visit.
● Prepare a list of questions to ask. List your most important questions first, to be sure that you cover those points.

For uterine fibroids, some basic questions to ask include:

● How many fibroids do I have? How big are they?
● Are the fibroids located on the inside or outside of my uterus?
● What kinds of tests might I need?
● What medications are available to treat uterine fibroids or my symptoms?
● What side effects can I expect from medication use?
● Under what circumstances do you recommend surgery?
● Will I need medication before or after surgery?
● Will my uterine fibroids affect my ability to become pregnant?
● Can treatment of uterine fibroids improve my fertility?

Make sure that you understand everything your doctor tells you. Don't hesitate to have your doctor repeat information or to ask follow-up questions.
 

What to expect from your doctor

Some questions your doctor might ask include:

● How often do you have these symptoms?
● How long have you been experiencing symptoms?
● How severe are your symptoms?
● Do your symptoms seem to be related to your menstrual cycle?
● Does anything improve your symptoms?
● Does anything make your symptoms worse?
● Do you have a family history of uterine fibroids?